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Single-Use Filter

The filtration process of CONTIBAC® SU and FUNDABAC® SU

Single-Use Filtration Technology

Our innovative single-use filters CONTIBAC® SU an FUNDABAC® SU drastically reduce your operating costs and extend the lifetime of your subsequent DSP equipment. They represent the ideal alternative to disposable filter cartridges for cell harvesting and clarification in biopharmaceutical processes. 

DrM’s single-use filters consist of multiple vertically aligned filter elements packed into a fully contained plastic enclosure. The plastic enclosure resembles a bag and is placed inside a transparent pressure vessel. The bag is then fed with cell suspension mixed with diatomaceous earth (DE), the latter constituting the filter aid material. The filter elements inside are designed for cake filtration and are covered with a filter membrane. The membrane acts as a support for the porous filter cake which performs the filtration and is formed during operation. The cake consists of cell material and DE.

Once the cake has grown to its maximum size, the bag is squeezed by conducting compressed air into the pressure vessel, thus filtering the heel volume. As a result, the flow rate is considerably enhanced as compared to conventional filter cartridges. More importantly however, the filter membrane is regenerated by back-flushing the cake with either WFI or buffer in the next step. 

The CONTIBAC® SU with its bottom port allows for discharging the washed down cake cyclically. This enables the deployment of comparably small filters for large batch or continuous bioreactors, as the cycles are repeated until the batch is finished. The FUNDABAC® SU which does not feature a discharge port can be deployed in cases, where the cell material shall remain contained inside the filter bag.

single-use filter 2L
Harvest your cells using only one filter per batch

Quit stacking, start cycling.

Advantages & Technical Information

Key advantages

  • High throughput
  • Increased yield in cell recovery and enzyme recovery operations
  • Shorter reactor downtime due to reduced cleaning and validation requirements
  • Pre-sterilised and validated filter enclosure available for pharma/biotech applications
  • Reduced heel volume and compaction of solid waste thanks to the external pressure
  • Fully enclosed containment made completely with plastics ensuring safe handling and disposal of hazardous components
  • Multilayered plastic bag providing superior robustness

Materials of construction

Filter BagPolyethylene PE
Filter ElementsPolyethylene PE
Filter HousingPolysulfone PSU / Stainless Steel
GasketSilicone
Connector MaterialPE, PP, PA, PVDF, PSU
ComplianceUSP Class VI
FDA 21 CFR 177
ISO/EMA
ASME BPE
Animal free material

Design figures

Max. Operating Pressureup to 4 bar (g)
Max. Temperatureup to 50 ºC
Sterilisation MethodGamma Sterilised or X-Ray Sterilised
Batch Volumeup to 1 lt, 5 lt, 10 lt, 50 lt, 100 lt, 200 lt, 1000 lt
Filtration AreaCustomized, available in various sizes*
Connector TypeHose Barb, Tri-Clamp, Sterile / Aseptic Connector, Luer

CONTIBAC® SU – Multi-cycle filtration with biomass discharge

CONTIBAC® SU Filtration
Filtration

During filtration, the suspension flows into the filter bag and is filtered through the filter membranes. The solid particles form the filter cake while the filtrate is extracted through a manifold.

CONTIBAC® SU Heel-Volume Filtration
Heel Filtration

After the cake has grown to its maximum size, compressed air is conducted into the pressure vessel, which squeezes the bag onto the filter elements. This ensures filtration of the remaining liquid heel.

CONTIBAC® SU Back-Flush
Back-Flush

The filtered solids are removed from the filter elements by introducing a liquid in reverse flow direction. The discharge port at the bottom allows accumulated solids to be back-flushed with WFI or buffer.

CONTIBAC® SU discharge
Discharge

After discharge the filter is ready to begin a new cycle. This significantly extends the lifetime of the filter bag and reduces operating cost.

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FUNDABAC® SU – Multi-cycle filtration with biomass sedimentation

FUNDABAC® SU Filtration
Filtration

During filtration, the suspension flows into the filter bag and is filtered through the filter membranes. The solid particles form the filter cake while the filtrate is extracted through a manifold.

FUNDABAC® SU Heel Volume Filtration
Heel Filtration

After the cake has grown to its maximum size, compressed air is conducted into the pressure vessel, which squeezes the bag onto the filter elements. This ensures filtration of the remaining liquid heel.

FUNDABAC® SU Back-Flush
Back-Flush

The filtered solids are removed from the filter elements by introducing a liquid in reverse flow direction. The back-flushed solids accumulate at the bottom of the filter bag, while the filter elements are regenerated for the next cycle.

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